• Mitochondrial dysfunction resulting from mtDNA abnormalities

  2023-08-17

  

  Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li

• br Conflicts of interest br

  2023-08-17

  

  Conflicts of interest Introduction Photodynamic Therapy (PDT) is a technique used for the treatment of several malignant and non malignant diseases (Akimoto, 2016, Keyal, Bhatta, Wang, 2016, Morton, Szeimies, Sidoroff, Wennberg, Basset-Seguin, Calzavara-Pinton, Gilaberte, Hofbauer, Hunger, Kar

• The previous reports studied only the apoptosis

  2023-08-17

  

  The previous reports studied only the apoptosis process in a single cell. In our case we generalized these models inspired by the results of Albeck et al. (2008) and Raychaudhuri et al. (2008), to study the apoptosis cell death after photodynamic therapy in those areas of the tumor that are not expo

• br Introduction AMP activated protein kinase AMPK has

  2023-08-16

  

  Introduction AMP-activated protein kinase (AMPK) has been found to be a key character against cardiovascular diseases and cellular stress. When activated by certain stress, AMPK regulates sugars and fatty acids that are good or detrimental to the heart. For example, targeting AMPK phosphorylation

• This development notwithstanding the chemotherapeutic treatm

  2023-08-16

  

  This development notwithstanding, the chemotherapeutic treatment for leukemia has stagnated over the last 40 years [35]. Main treatment options necessitate aggressive chemotherapy to target leukemic cells [36], [37], [38], [39]. Several limitations of current treatment options include the use of ant

• Imaging QTL studies may have several potential

  2023-08-16

  

  Imaging QTL studies may have several potential advantages over case-control studies, including increased power . Imaging endophenotypes of disease in QTL studies can separate patients and normal subjects more accurately and therefore limit the confound of including asymptomatic subjects in the cont

• br Discussion Missense mutations transversions of

  2023-08-16

  

  Discussion Missense mutations (transversions) of the first nucleotide of the phenylalanine HBC at position 1174 (F1174) of the anaplastic lymphoma kinase gene can result in substitutions to leucine or valine (F1174L/V) while missense mutation (transversion) of the second nucleotide of the phenyl

• br Experimental section br Results and discussion

  2023-08-16

  

  Experimental section Results and discussion Conclusions We present a simple, sensitive and selective assay of ADA activity and its inhibitor using the enzyme catalyzed reaction and the different interaction intensity of dye-labeled AD aptamer, aptamer/AD complex with GO. The as-proposed met

• We have previously reported alterations of the thymus in ACh

  2023-08-16

  

  We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center 5-EdU (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, suggesting that autoreac

• It has been reported that leukotrienes and

  2023-08-16

  

  It has been reported that leukotrienes and their receptors, e.g. the cysteinyl leukotriene receptor 1 (CysLT1) may promote Cy3 RNA injury (Ding et al., 2007) and that increased 5-LOX expression and activity lead to production of brain-toxic molecules (Khan et al., 2010). However, differential effec

• Acknowledgements The work was supported by grants from Swedi

  2023-08-16

  

  Acknowledgements The work was supported by grants from Swedish Research Council (J.Z.H.) (A.R.M.). We thank Protein Science Facility (PSF), Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. We thank Prof. Ralf Morgenstern (Department for Environmental Medic

• 2-Palmitoylglycerol mg br Increased blood ATX and LPA in liv

  2023-08-16

  

  Increased blood ATX and LPA in liver fibrosis Although previous in vitro findings have suggested a link between LPA and liver fibrosis in vivo, whether LPA plays a primary role in the pathogenesis of liver fibrosis has remained uncertain. No phenotypic changes in livers of LPA receptor-deficient

• br Results br Discussion br Conclusion The flux of glucose

  2023-08-16

  

  Results Discussion Conclusion The flux of glucose into cytosolic short chain acyl-CoAs was maintained in pure beta ω-Agatoxin TK in the presence of inhibition of ATP citrate lyase with hydroxycitrate and also in a cell line with >90% ATP citrate lyase knockdown suggesting that a pathway oth

• Introduction Lipoxygenases LOXs are key enzymes

  2023-08-16

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic Cap Firefly Luciferase mRNA (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other c

• Thus a majority of known chemical and physico chemical

  2023-08-15

  

  Thus, a majority of known chemical and physico-chemical methods of metallic ions assay has a number of disadvantages, such as a low sensitivity and selectivity, high costs and complexity of the equipment. Therefore, the development of simple cost-effective sensitive methods of quantitative analysis

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