• Ageing is associated with increased reactive oxygen

  2020-08-03

  

  Ageing is associated with increased reactive oxygen species (ROS) production, oxidative stress and oxidative damage [43,44]. Overproduction of ROS can impair endothelial function by suppressing NO synthesis and scavenging NO thereby decreasing its overall bioavailability. Moreover, sustained oxidati

• thiotepa cGAS has a central role in

  2020-08-03

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• br Results and discussion In the

  2020-08-03

  

  Results and discussion In the present study, we used a set of compounds (Fig. 2) consisting of ATP (a), dATP (b), an ATP analog containing β,γ-nonhydrolyzable hypophosphate P-P bond (c), and three pairs of P-diastereoisomers of α-thio-ATP analogs (d,e,f) containing a sulfur XEN445 mg instead of o

• Our previous studies have demonstrated that the

  2020-08-03

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• (-)-Bicuculline methobromide The roles of FGF and SHP as reg

  2020-07-31

  

  The roles of FGF19 and SHP as regulators of sterol metabolism and transport extend beyond the intestine. Recent SHP ChIP-sequencing studies in livers of FGF19-treated mice showed that SHP inhibits expression of sterol biosynthetic network genes, including Hmgcr, as well as BA synthetic genes. FGF19

• Celiac disease occurs in the small

  2020-07-31

  

  Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they

• DDR kinases are linked to

  2020-07-31

  

  DDR kinases are linked to the progression of various human diseases, including fibrotic disorders, atherosclerosis and cancer [9], [12], [13]. Significantly, they are identified as indicators of poor prognosis in ovarian, breast and lung cancer [14], [15], [16]. DDR1 overexpression is associated wit

• br Conclusions Since collagens were first identified as

  2020-07-31

  

  Conclusions Since collagens were first identified as ligands for the DDRs, we have gained a good understanding of the structural basis of ligand recognition. We also have gained many insights into the in vivo functions of DDRs and the roles they play in development and disease. However, many myst

• Being an in vitro study it

  2020-07-31

  

  Being an in vitro study it has some limitations before it can be translated to the clinic. We investigated several cell models in which the results on EMT or ACF are not always identical. We selected the models to be complementary, we saw that EMT induction by stimulation (TGF-β1 or CoCl2) is functi

• In the current study cocaine

  2020-07-31

  

  In the current study, cocaine did not significantly increase negative subjective effects and nepicastat did not increase these responses. This outcome is somewhat surprising given that the most commonly reported effect to date has been to increase the aversive properties of cocaine such as anxiety,

• Regarding the COMT haplotype and MDD

  2020-07-31

  

  Regarding the COMT haplotype and MDD treatment response, a previous study of haplotype C-C-A of exonic SNPs, rs4633, rs4818, and rs4680 correlated the treatment response phenotypes, and detected haplotype CCA more often in responders than non-responder and controls (Kocabas et al., 2010). In our stu

• Acknowledgements We thank the University

  2020-07-30

  

  Acknowledgements We thank the University of Hull for funding, BBSRC for support (GM), and the EPSRC National Mass Spectrometry Service (Swansea) for accurate mass determination of 2e and 3e. Introduction Mitochondria are vital organelles for most eukaryotic cells (Karnkowska et al., 2016). They

• br Introduction The stroma associated with

  2020-07-30

  

  Introduction The stroma associated with breast cancer metastasis consists of extracellular matrix (ECM) proteins, including fibrillar collagens, and a cellular component comprised of mesenchymal stem/multipotent stromal (-)-Bicuculline methiodide (MSCs), vessels, and cells of the immune system (P

• Additionally studies of Wang et

  2020-07-30

  

  Additionally, studies of Wang et al. (2015) have revealed that transcripts of all identified rice cystatins, independently of their phylogenetic position, have been found during the whole seed development, however their expression levels were different depending on the stage of this process. Most of

• Studies with CysLT receptor antagonists have

  2020-07-30

  

  Studies with CysLT receptor antagonists have always provided a controversial picture on the role for cysteinyl-LTs in the development of ischemic damage and in cardiac dysfunction, with conclusions often contradicting each other. Indeed, recent evidence showed that montelukast, zafirlukast and pranl

15210 records 772/1014 page Previous Next First page 上5页 771772773774775 下5页 Last page