• br Materials and methods br Statistical

  2020-08-04

  

  Materials and methods Statistical analysis GraphPad Prism (GraphPad Software, Inc. La Jolla, USA) was used for all statistical analyses. Statistical analysis was conducted using either the t-test or the Bonferroni Multiple Comparisons Test: *p  Results Discussion CCA is a fatal tumor orig

• Despite the important role of ubiquitination dependent mecha

  2020-08-04

  

  Despite the important role of ubiquitination-dependent mechanisms in DSB repair (Jackson and Durocher, 2013), UbL73P displayed no global defects in DNA repair mechanisms following bleomycin treatment or ionizing radiation, perhaps because UbL73P was incompletely utilized or because the need for deub

• These findings are of great importance

  2020-08-04

  

  These findings are of great importance to the aging field because they uncover a novel mechanism by which accumulation of DNA damage leads to functional decline during aging. The role of DNA damage in aging has been a subject of debate (Campisi and Vijg, 2009). Clearly, artificially increased levels

• Some recent research indicates that TGF

  2020-08-03

  

  Some recent research indicates that TGF-β1 can stimulate EP300 in inflammation, fibrosis and cancer [28]. Beyond the typical transcriptional cofactor, EP300 can regulate target gene vitamin k3 without directly binding to DNA by possessing intrinsic acetyltransferase activity. EP300 plays an importan

• Recently several Pt IV complexes as prodrugs

  2020-08-03

  

  Recently, several Pt(IV) complexes as prodrugs have been designed and studied to enhance anti-tumor efficacy of traditional Pt(II) drugs, improving their cellular uptake and blood-circulation time [26], [27], [28], [29]. Compared with their Pt(II) counterparts, six-coordinated Pt(IV) complexes with

• br STAR Methods br Acknowledgments We

  2020-08-03

  

  STAR★Methods Acknowledgments We would like to thank the DNA cloning, Protein Production, DNA sequencing facility, and mass spectrometry teams of the MRC Protein Phosphorylation and Ubiquitylation Unit for their support. We would like to thank Prof. Dario Alessi, Prof. Ronald Hay, Prof. Philip

• Oysters belong to the second largest animal phylum Mollusca

  2020-08-03

  

  Oysters belong to the second largest animal phylum Mollusca, and they are globally distributed aquaculture animals (Wang et al., 2018). A number of studies have demonstrated that oysters have evolved an integrated and complex innate beta-lactamase to recognize and eliminate various invaders. An arr

• ICT is a product of icariin via the metabolism

  2020-08-03

  

  ICT is a product of icariin via the metabolism of intestinal bacteria with estrogen-like activities [33]. ICT as a bone-protecting agent can enhance osteoblast differentiation while suppressing osteoclastic differentiation in vitro [19], and stimulate osteogenic differentiation and inhibit adipogene

• Ageing is associated with increased reactive oxygen

  2020-08-03

  

  Ageing is associated with increased reactive oxygen species (ROS) production, oxidative stress and oxidative damage [43,44]. Overproduction of ROS can impair endothelial function by suppressing NO synthesis and scavenging NO thereby decreasing its overall bioavailability. Moreover, sustained oxidati

• thiotepa cGAS has a central role in

  2020-08-03

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• br Results and discussion In the

  2020-08-03

  

  Results and discussion In the present study, we used a set of compounds (Fig. 2) consisting of ATP (a), dATP (b), an ATP analog containing β,γ-nonhydrolyzable hypophosphate P-P bond (c), and three pairs of P-diastereoisomers of α-thio-ATP analogs (d,e,f) containing a sulfur XEN445 mg instead of o

• Our previous studies have demonstrated that the

  2020-08-03

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• (-)-Bicuculline methobromide The roles of FGF and SHP as reg

  2020-07-31

  

  The roles of FGF19 and SHP as regulators of sterol metabolism and transport extend beyond the intestine. Recent SHP ChIP-sequencing studies in livers of FGF19-treated mice showed that SHP inhibits expression of sterol biosynthetic network genes, including Hmgcr, as well as BA synthetic genes. FGF19

• Celiac disease occurs in the small

  2020-07-31

  

  Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they

• DDR kinases are linked to

  2020-07-31

  

  DDR kinases are linked to the progression of various human diseases, including fibrotic disorders, atherosclerosis and cancer [9], [12], [13]. Significantly, they are identified as indicators of poor prognosis in ovarian, breast and lung cancer [14], [15], [16]. DDR1 overexpression is associated wit

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