• One possible explanation for differences in the

  2019-07-17

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• In summary our data show a novel mechanism

  2019-07-17

  

  In summary, our data show a novel mechanism: CPD-mediated autoprocessing of C difficile toxins regulates their proinflammatory activities. Thus, our study provides a new understanding of the molecular mechanisms of the pathogenesis of C difficile toxins and insights into designing new therapeutics a

• It has been reported that NMDA receptor hypofunction upregul

  2019-07-17

  

  It has been reported that NMDA receptor hypofunction upregulates the expression of immediate early genes in several SR 11302 regions [39], [40]. Consistent with this finding, we demonstrated that MK-801 increased the number of c-Fos-positive cells in the PVN and PC/RS (Fig. 5). Importantly, the MK-8

• Oleandrin To extend these toxicity minimization strategies t

  2019-07-17

  

  To extend these toxicity minimization strategies to 3D tissues, a more complicated mass transfer model is necessary to account diffusion in the interstitial space, as well as transport across cell membranes. Until recently, tissue mass transport in cryobiology was modeled using classic spatially dep

• Molecular modelling studies were performed

  2019-07-16

  

  Molecular modelling studies were performed on the hDHFR inhibitors identified (1, 11, 13, 14, 16, 25 and 32) to explore the structural basis of the interaction between the mentioned compounds and the human enzyme. The docking studies were performed using the X-ray crystallographic structure of the h

• br DGAT proteins lipid droplets and

  2019-07-16

  

  DGAT proteins, lipid droplets and cancer cells Conclusions and future directions Conflicts of interest Acknowledgements This work was supported by NIH grants GM062887, P01CA097132, and Veterans Affairs Merit Award to LMO. Introduction Bioethanol and biodiesel are regarded as the two

• br Materials and methods br Results br Discussion

  2019-07-16

  

  Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated leukotriene receptor antagonist guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated

• br Material and methods br Results br

  2019-07-16

  

  Material and methods Results Discussion Conclusions To conclude, although CPT2 and CPT1 must have co-evolved to establish the carnitine shuttling, these enzymes are the most distantly related carnitine transferases, split early in evolution, during which a switch occurred in their locati

• Various domains of the HSA molecule have also been

  2019-07-16

  

  Various domains of the HSA molecule have also been used to make bioconjugates with increased stability, better targeting properties, and/or extended half-lives in blood. For example, domain I of HSA has been used in the preparation of antibody conjugates. This was achieved through the use of a cyclo

• XI-006 for The detection of galactomannan GM a polysaccharid

  2019-07-16

  

  The detection of galactomannan (GM), a polysaccharide that is released during Aspergillus growth, is a useful and reliable non-invasive diagnostic test for screening and management of aspergillosis and is often more sensitive than culture (Schelenz et al., 2015, Fisher et al., 2013). The level of ga

• Lonafarnib EphB and ephrinB mRNA levels were determined

  2019-07-16

  

  EphB4 and ephrinB2 mRNA levels were determined from three parts taken from each tumor, and each sample was analyzed in triplicate. The differences in the histoscores and mRNA levels of EphB4 and ephrinB2 were analyzed by Student\'s t test. The correlation coefficients were evaluated both by linear r

• How does an increase in E affinity for the

  2019-07-16

  

  How does an increase in E2 affinity for the RING domain favor higher activity and polyubiquitination by the E2? Binding of the RING domain to the E2 positions the donor Ub in the E2~Ub conjugate in a closed complex [16], [17], [18] that increases the reactivity of the thioester [60]. A higher affini

• NVP-BGJ398 phosphate The yeast Rad p radiation sensitive als

  2019-07-16

  

  The yeast Rad6p (radiation sensitive 6, also called Ubc2) E2 ubiquitin-conjugating enzyme is a member of the highly conserved UBC proteins in eukaryotes (Xu et al., 2009). Rad6p is involved in several cellular processes, including DNA repair, transcriptional activation and silencing, histone ubiquit

• The quaternary structure of many of the family

  2019-07-16

  

  The quaternary structure of many of the family B members (i.e., secretin, glucagon, glucagon-like peptide and Physcion receptors) have been actively studied and it has been demonstrated that they can form homodimers/oligomers (Gao et al., 2009; Ng & Chow, 2015; Ng, Lee, & Chow, 2013). Harikumar, Pi

• br Materials and methods br Results

  2019-07-15

  

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th

15877 records 1013/1059 page Previous Next First page 上5页 10111012101310141015 下5页 Last page