• br Conformational control inhibition Conformational escape r

  2019-04-20

  

  Conformational control inhibition Conformational escape resistance is a phenomenon where point mutations (such as T315I) drive the Abl kinase toward the active type I state. “Switch-control inhibitors” bind in a non-ATP-competitive fashion to residues (E282, R386) the Abl protein uses to switch b

• br is a bacterial infection causing

  2019-04-20

  

  is a bacterial infection causing necrotising lesions of skin and subcutaneous tissue. Widely known as Buruli ulcer, it is classified as a neglected tropical disease by WHO. If diagnosed and treated early, outcomes are good, but if left untreated it can progress to a severe disease resulting in hig

• Blunt snout bream Megalobrama amblycephala is

  2019-04-20

  

  Blunt snout bream (Megalobrama amblycephala) is an herbivorous freshwater fish native to China. Due to its fast growth, tender flesh, and high disease resistance, it has been a favorable candidate for aquaculture in China. However, it is prone to bacterial and viral diseases and is relatively sensit

• In our study ES SCLC patients in

  2019-04-19

  

  In our study, ES-SCLC patients in the CIT group were on average older than those in the control group. However, the multivariate analysis showed that age had no effect on the prognosis of these patients. Therefore, age was no a confounding factor, although it has been reported that effector cell fun

• br Methods br Results br Discussion

  2019-04-19

  

  Methods Results Discussion Conclusions Author contributions Disclosures and funding sources Conflicts of interest Introduction Head-up tilt (HUT) testing has become a widely accepted diagnostic tool for the evaluation of neurally mediated syncope (NMS), which is a major cause

• One week after the CCRT she was brought to

  2019-04-19

  

  One week after the CCRT, she was brought to our emergency department due to fever, severe general weakness, and severe oral pain. Her Sicca syndrome-related xerostomia had worsened due to radiotherapy and was complicated with severe stomatitis, which made oral intake difficult. She took traditional

• Finally MM patients have accelerated bone loss when compared

  2019-04-19

  

  Finally, MM patients have accelerated bone loss when compared to age-matched controls. Bone mineral density is decreased in patients with MM as well as in patients with monoclonal gammopathy of undetermined significance (MGUS) [19,20], a clinically benign condition defined by a low level of monoclon

• br Tuberculosis remains a global emergency and continues to

  2019-04-19

  

  Tuberculosis remains a global emergency and continues to present major public health challenges worldwide. The actual global burden of tuberculosis can only be estimated because no accurate data are available from national country programmes from of high tuberculosis endemic countries. The WHO 201

• Magall n es muy claro al decir

  2019-04-19

  

  Magallón es muy claro al decir que la aplicación de las políticas neoliberales en América Latina no significaron cohesión social ni la apropiación de la idea “necesaria” de humanidad. “El mayor problema de estos países sigue siendo la pobreza, la desigualdad social y de oportunidades, la desigualdad

• El n mero de ofrece

  2019-04-18

  

  El número 62 de ofrece, en una primera sección, tres artículos que se ubican en los campos de la literatura, las revistas culturales y en general las redes intelectuales en América Latina. Lucía Di Salvo León y Patricio Herrera González, en “¿Una poética del exilio? La revista y el exilio republica

• br Discussion In this study

  2019-04-18

  

  Discussion In this study, AT originated in the orifice of the RAA in a patient with ARVC/D. The origins of these ATs were quite close, which is supported by similar P-wave morphology of each AT. The ATs could be ablated by multiple endocardial RF applications. In this case, the exact mechanism un

• During the ACh provocation test our patient

  2019-04-18

  

  During the ACh provocation test, our patient did not complain of chest pain, ECG showed no discernible ST-T changes, and CAG demonstrated no spastic findings. These indicate that ACh evoked the J wave by its direct pharmacological actions in this case. J waves are currently recognized as a surface E

• La eleg a de tus

  2019-04-18

  

  “La elegía de tus ojos” (1914) Uno de los poemas más tempranos de Pellicer, “La elegía de tus ojos”, ya demuestra un sentido nuevo de historicidad. Escrito en 1914, en el apogeo del posmodernismo y durante la Revolución mexicana, cuando el poeta tenía apenas unos quince años, este poema se adhiere

• br Practical management of perioperative anticoagulation

  2019-04-18

  

  Practical management of perioperative anticoagulation and antiplatelet therapy in CIED surgery By integrating the current literature and the experience from our own practice, we developed a practical algorithm recently to guide the perioperative management of anticoagulation and antiplatelet ther

• bosentan In this study all tumors were

  2019-04-18

  

  In this study, all tumors were Campanacci stage 3, which is a significantly higher proportion than in our database [9]. Such a high stage usually suggests that a tumor is highly aggressive and may be a high-risk factor for lung metastasis. Previous reports have also suggested that the stage of a GCT

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