• More recently primary tumor driven generation of

  2019-04-26

  

  More recently, primary tumor driven generation of a bone pre-metastatic niche was observed in a mouse model of estrogen receptor-negative breast cancer metastasis. Specifically, lysyl oxidase (LOX) secreted into the circulation from hypoxic primary breast tumors disrupted bone homeostasis, thereby i

• br Reflexionar sobre esta frase

  2019-04-26

  

  Reflexionar sobre esta frase, que aparece temprano en , es vislumbrar una versión concentrada del libro entero. Digo bien una versión, pues se podrían expresar otras dinámicas igualmente representativas de la obra al reemplazar las palabras ‘fijeza’ y ‘cambio’ por ‘destrucción’ y ‘renovación’, ‘de

• Una recopilaci n impresa del

  2019-04-26

  

  Una recopilación impresa del trabajo que realizó con su cámara, desde 1980 hasta 1986, fue publicado con el título: Guatemala: Eternal Spring, Eternal Tyranny en 1988. En 2010 reeditó el libro en español, el cual se difundió ampliamente en Guatemala como parte del proceso de recuperación histórica.

• The primary outcome was local recurrence or metastasis The

  2019-04-26

  

  The primary outcome was local recurrence or metastasis. The secondary outcome included functional outcome based on Musculoskeletal Tumor Society (MSTS) score. Data for the study were retrieved from hospital records, maintained oncological files, surgical files, and clinical examination at the most r

• The patient had experienced cardiopulmonary arrest

  2019-04-26

  

  The patient had experienced cardiopulmonary arrest because of PEA and bradycardia at least twice while on oral treatment for variant angina, but neither ventricular fibrillation nor ventricular tachycardia was apparent. Spontaneous attacks occurred despite the use of an oral calcium blocker, and low

• br Bisphosphonate use and breast cancer risk

  2019-04-26

  

  Bisphosphonate use and breast cancer risk BPs are commonly used in the management of postmenopausal osteoporosis. They consist of two phosphate groups, which give them a high affinity to bone. They attach to bone at exposed calcium hydroxyapatite binding sites, which are most accessible at sites

• The multivariable Cox regression model also showed that pati

  2019-04-25

  

  The multivariable Cox regression model also showed that patients who were divorced, separated, or widowed had a significantly worse outcome than patients who were married or single; the mortality rate for Divorced, Separated or Widowed PLB patients was estimated to be 1.4 times that for married pati

• Preclinical studies have shown that adipocytes

  2019-04-25

  

  Preclinical studies have shown that adipocytes and MSCs play an important role in migration and dissemination of cancer xanthine oxidase inhibitors [55,56]. Concerning osteosarcoma, one publication has reported that human MSCs injected through the caudal vein of mice bearing Saos-2- induced an incre

• La categorizaci n propuesta por Margaret Randall

  2019-04-25

  

  La categorización propuesta por Margaret Randall es mucho más simple, puesto que distingue tan sólo entre aquellos testimonios en sí de los testimonios para sí. Christina Dupláa analiza tal distinción: Como puede verse, la clasificación es bastante difusa, ya que en la primera categoría se consider

• Cardiologic examination and detailed analysis

  2019-04-25

  

  Cardiologic examination and detailed analysis of 12-lead rest ECG were performed by an experienced cardiologist (E.C.) and reevaluated by another independent cardiologist (S.R.). According to Groh et al., severe ECG abnormality included at least one of the following: rhythm other than sinus; PR inte

• br Discussion Early repolarization is

  2019-04-25

  

  Discussion Early repolarization is a common ECG characteristic. Its reported prevalence is 6–25% of the general population, and is particularly common in athletes [2,3,11,12]. It is now recognized that a small fraction of people with early repolarization on their ECGs develop lethal tachyarrhythm

• br Panels A to D

  2019-04-25

  

  Panels A to D show intracardiac recordings of the HRA extrastimuli with A1A2 intervals of 320−290ms at a basic CL of 600ms. The AV conduction intervals were increased gradually rather than suddenly, so that an Ae with an A2–V2–Ae sequence could be provoked only at 310ms and 300ms, followed by no A

• The status of Fas and Fas

  2019-04-25

  

  The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma. These results suggest that the evaluation of Fas and Fas ligand expression potentially has a significant prognostic value for DFS of HCC patients, in addition to patient clinical stage, and can be regarde

• In summary current evidence suggests that bone targeted agen

  2019-04-25

  

  In summary, current evidence suggests that bone-targeted agents reduce morbidity from metastatic disease to bone, and potentially improve quality of life in patients with metastatic breast cancer. As there are costs and potential adverse effects associated with these agents, care should be taken in

• Intravenous injection of B F melanoma cells in Nf

  2019-04-25

  

  Intravenous injection of B16F10 melanoma cells in Nf-E2-/-mice produces markedly less lung metastatic lesions compared to that in wildtype mice [5]. This provides one of the strongest confirmations for the role of platelets in hematological dissemination of tumor cells although bone tissues were not

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