• VEGFR inhibition using sunitinib does not result in tumor gr

  2024-08-01

  

  VEGFR2 inhibition using sunitinib does not result in tumor growth reduction or in a further decrease in vessel density in NDRG1 overexpressing glioma rendering these tumors intrinsically resistant to antiangiogenic treatment. Intrinsic resistance to antiangiogenic therapy is defined as a non-respons

• br Introduction Metabolic cues are

  2024-08-01

  

  Introduction Metabolic cues are crucial inputs in dictating acute responses through governing cellular signaling pathways as well as in shaping up long-term transcriptional and epigenetic profiles to control chronic cellular responses (Lu and Thompson, 2012). It has been well documented that meta

• Epidermal growth factor EGF has been shown to increase the

  2024-08-01

  

  Epidermal growth factor (EGF) has been shown to increase the 12S-lipoxygenase mRNA level by about two-fold in human epidermoid carcinoma A431 cells [71]. This enzyme was shown to be of the platelet-type and associated with the microsomal fraction of the cells [71], [72]. A requirement for EGF recept

• As one of emerging high throughout methods metabolomics dete

  2024-08-01

  

  As one of emerging high-throughout methods, metabolomics detects metabolites which are ultimate response of biological systems to environmental changes [14]. Metabolomics uncovers metabolic alteration at the systems level. Comparison of global metabolic profiling reflects some unidentified biologica

• br Liver specific AHR deficiency

  2024-08-01

  

  Liver-specific AHR deficiency and energy balance In contrast to the amelioration of hepatic steatosis by global AHR deficiency, targeted knockout of Ahr in hepatocytes exacerbated it in B6 mice fed on a high-fat diet, without interfering with body weight gain [21]. This appeared to result from au

• 59 7 mg The direction of glutamate transport by the cell mem

  2024-08-01

  

  The direction of glutamate transport by the cell membrane transporter is reversible. As mentioned above, glutamate transport is an electrogenic process associated with a transmembrane ion gradient established by the Na+-K+ pump through hydrolysis of adenosine triphosphate. Under conditions of energy

• These results from the present study are summarized in Table

  2024-08-01

  

  These results from the present study are summarized in Table 1. Eight drugs (doxorubicin, epirubicin, daunorubicin, idarubicin, irinotecan, imatinib, sunitinib and gefitinib) inhibited 5-HT-induced 5-HT3A and 5-HT3AB currents; three (irinotecan, topotecan and mitoxantrone) showed different responses

• In the previous study we demonstrated the importance of

  2024-08-01

  

  In the previous study, we demonstrated the importance of the mPFC postsynaptic 5-HT1A receptor in the sustained antidepressant effects, because a sustained antidepressant effect was obtained with intra-mPFC injection, but not systemic injection of 8-OH-DPAT, a 5-HT1A receptor agonist (Fukumoto et al

• Tadalafil When added to the culture medium extracellular

  2024-08-01

  

  When added to the culture medium, extracellular ATP is metabolized into adenosine by ectonucleotidases, and ARs are then activated by adenosine with concentrations in the micromolar range [27]. However, our study showed that activation of ARs by exogenous adenosine could not induce the odontoblastic

• In the past years the role of the CD adenosinergic

  2024-08-01

  

  In the past 10 years, the role of the CD73-adenosinergic pathway in suppression of anti-tumor immunity has increasingly been recognized [13], [14]. In this review, we discuss the latest findings dealing with the regulation of anti-tumor immunity by CD73 and adenosine. We also discuss ongoing clinica

• br Expression of ADK in

  2024-08-01

  

  Expression of ADK in the normal brain In adult brain, ADK is primarily expressed in astrocytes. Immunocytochemical analysis of adult rat and mouse SKL2001 australia revealed predominant astrocytic expression throughout the hippocampus and cortex. Two isoforms of ADK have been identified in mammal

• gp120 Docking studies were performed on the selected

  2024-07-31

  

  Docking studies were performed on the selected compounds to explore their binding patterns and to examine SAR in more detail. The co-crystal structure of ATX in complex with PF-8380 (PDB code: ) was selected for the docking studies due to structural similarity of the most potent compound with PF-838

• br Introduction The process of mitosis

  2024-07-31

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the Vinorelbine ditartrate resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in

• Our results suggest that plasma membrane and

  2024-07-31

  

  Our results suggest that plasma membrane and a3-containing V-ATPases represent an important and novel target in the development of drugs to limit breast cancer metastasis. That knock-down of a3 has been shown to reduce metastasis of melanoma cells in an in vivo mouse model suggests that this role ma

• AP activation is known to

  2024-07-31

  

  AP-1 activation is known to upregulate downstream target genes including nitric oxide booster D1, c-myc, Bcl-xl, MMP-9, EGFR, and specific miRNAs that are involved in progression and metastasis of tumors. Moreover, matrix metalloproteinase-2 has been shown as a downstream gene of AP-1, triggered by

15863 records 106/1058 page Previous Next First page 上5页 106107108109110 下5页 Last page